A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

Neurons are highly polarized cells with a single axon and multiple dendrites derived from the cell body to form tightly associated pre- postsynaptic compartments. As biosynthetic machinery is largely restricted somatodendritic domain, vast majority of presynaptic components synthesized in neuronal soma, packaged into synaptic precursor vesicles, actively transported along sites biogenesis. In contrast significant progress that has been made understanding transmission processing information at post-synapse, comparably little known about formation dynamic remodeling compartment. We review here our current mechanisms govern biogenesis, transport, assembly key for neurotransmission, discuss how alterations may impact nervous system function or lead disease, outline open questions future research. cells, deriving body. Synapses formed predominantly during development as axons establish contacts somata but continues mature throughout postnatal life (Südhof, 2018Südhof T.C. 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